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In SURPASS-2, which compared tirzepatide to semaglutide (a GLP-1 receptor agonist) in patients taking metformin, tirzepatide 5 mg, 10 mg, and 15 mg doses achieved mean HbA1c reductions of 2.01%, 2.24%, and 2.30% respectively from baseline, compared to 1.86% with semaglutide 1 mg

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However, the FDA often exercises enforcement discretion. This means they may allow small quantities (usually a 90-day supply) to be imported if the drug is for a serious condition, there is no effective treatment available in the US, and the individual provides the name of their US-licensed treating physician

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